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US 11,878,994 B1Granted
Compositions for treatment of inflammation
AssigneeMetro International Biotech, LLC
InventorsJames M. McKearin, David J. Livingston, Karen Lavery
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Abstract
Disclosed herein are novel compositions and methods for the treatment of inflammation. Also described herein are methods for the identification of agents useful in the foregoing methods. The invention relates to methods for treatment and prevention of disorders associated with inflammation by administering agents that may also increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.
Claims30
A compound having a structure represented by Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein
- (i) Q is H or —PO(OH)2 or —PO(OH)(O−);
- (ii) Y is —NH— or —O—;
- (iii) L2 is
- (a) (C1-6)alkylene or
- (b)
- wherein
- L2a is (C1-C6)alkylene;
- each RA is independently OH, O−, O-alkyl, NH-alkyl, or alkyl;
- Z is O or NH;
- n is 0 or 1;
- * is the point of attachment to Y;
- ** is the point of attachment to D;
- and
- (iv) D is an optionally substituted xanthine.
12 more elements
Dependencies are inferred from the claim text.