Sonodynamic therapy
AssigneeUniversity of Ulster
InventorsJohn Callan, Anthony Mchale, Sukanta Kamila, Keiran Logan
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Abstract
The invention relates to microbubble complexes for use in methods of sonodynamic therapy which comprise a microbubble attached to or otherwise associated with one or more linking groups, each linking group being bound to at least one sonosensitising agent and at least one chemotherapeutic agent. It further relates to the microbubble complexes themselves and to pharmaceutical compositions which contain them. The invention is particularly suitable for the treatment of deep-sited tumors, in particular pancreatic cancer.
Claims21
A microbubble complex which comprises a microbubble attached to a plurality of linking groups, each linking group having three branches wherein a first branch of the linking group is bound to the microbubble, a second branch of the linking group is linked to a chemotherapeutic agent and a third branch of the linking group is linked to a sonosensitising agent, wherein said chemotherapeutic agent is an anti-metabolite or an anthracycline, and said sonosensitising agent is selected from the group consisting of phenothiazine dyes, Rose Bengal, porphyrins, chlorins, benzochlorins, phthalocyanines, napthalocyanines, porphycenes, cyanines, azodipyromethines, acridine dyes, purpurins, pheophorbides, verdins, psoralens, hematoporphyrins, protoporphyrins and curcumins.
Dependencies are inferred from the claim text.