Combination therapy for ischemia
AssigneeNoNO Inc.
InventorMichael Tymianski
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Abstract
The invention provides a combination treatment for ischemia conditions in or otherwise affecting the CNS, such as stroke. The treatment involves administration of a PSD-95 inhibitor and performing reperfusion therapy (e.g., by administration of tPA). Administering a PSD-95 inhibitor in combination with reperfusion therapy increases the efficacy of the reperfusion therapy and/or slows the decline in efficacy of reperfusion therapy with time after onset of ischemia thus extending the window in which reperfusion therapy can be administered.
Claims20
A method of treating stroke, comprising
- administering a PSD-95 inhibitor comprising a peptide comprising SEQ ID NO:38 or SEQ ID NO:68 at its C-terminus, the peptide being linked to an internalization peptide to a human subject having or at risk of stroke, and performing reperfusion therapy on the subject, wherein the PSD-95 inhibitor and reperfusion therapy synergistically treat the stroke.
A method of treating a subject population of humans subjects presenting sign(s) and/or symptom(s) of stroke, comprising administering a PSD-95 inhibitor comprising a peptide comprising SEQ ID NO:38 or SEQ ID NO:68 at its C-terminus, the peptide being linked to an internalization peptide, to the human subjects;
- wherein the human subjects are analyzed for unacceptable risk of side effects of reperfusion therapy, some of the subjects having unacceptable risk of side effects of reperfusion therapy and some of the subjects not having unacceptable risk of side effects of reperfusion therapy, and the human subjects without unacceptable risk of side effects receive reperfusion therapy and the human subjects with unacceptable risk of side effects do not receive reperfusion therapy, and wherein in the human subjects without unacceptable risk of side effects receiving reperfusion therapy, the reperfusion therapy and the PSD-95 inhibitor synergistically treat the stroke.
Dependencies are inferred from the claim text.