Arsinothricin as a multi-stage antimalarial
AssigneeThe Florida International University Board of Trustees
InventorsMasafumi Yoshinaga, Barry P. Rosen, Jun Li, Guodong Niu
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Abstract
The subject invention provides arsinothricin (AST) or salts thereof, and compositions comprising AST or a salt thereof for use as multi-stage antimalarials. The subject invention also provides methods for treating, inhibiting and/or preventing malaria infection and transmission by using AST or salts thereof, or compositions comprising AST or a salt thereof. Advantageously, AST or a salt thereof inhibits glutamine synthetase (GS) of malaria pathogens without exhibiting cytotoxicity to human host.
Claims20
A method of treating malaria infection in a subject in need thereof comprising administering to the subject arsinothricin (AST) or a salt thereof.
A method of inhibiting or reducing malaria transmission, the method comprising administering to a subject arsinothricin (AST) or a salt thereof.
A method of inhibiting or reducing the growth of malaria parasite in a subject having malaria, the method comprising administering to the subject AST or a salt thereof.
Dependencies are inferred from the claim text.