Multi-modal ionization for mass spectrometry
AssigneeBaySpec, Inc.
InventorsNam Duc Lai, Krisztian Gabor Torma, Ming Chai, William Allen Escobar, Xiaoguang Wu, Masayuki Kamata, Wei Yang Terziyan
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Abstract
Techniques and systems for multi-modal ionization for mass spectrometry are provided. In some embodiments, a method may comprise: receiving an analyte; ionizing some molecules of the analyte using a first ionization method to produce first ions; ionizing other molecules of the analyte using a second ionization method to produce second ions; and providing the first and second ions to a mass analyzer.
Claims19
A method for multi-modal ionization comprising:
- receiving an analyte;
- ionizing some molecules of the analyte using a first ionization method and a first ionization source to produce first ions;
- ionizing other molecules of the analyte using a second ionization method and a second ionization source to produce second ions;
- and
- providing the first and second ions to a mass analyzer, wherein the second ionization source comprises a counter electrode and a high-voltage electrode separated by a dielectric barrier, and wherein an end of the dielectric barrier and an inlet of the mass analyzer are electrically coupled to a ground.
A system for multi-modal ionization, the system comprising:
- an inlet receiving an analyte;
- a first ionization source coupled to the inlet, the first ionization source ionizing some molecules of the analyte to produce first ions;
- and
- a second ionization source coupled to the first ionization source, the second ionization source ionizing other molecules of the analyte to produce second ions, wherein the first ions and the second ions are provided to a mass analyzer, and wherein the second ionization source comprises a counter electrode and a high-voltage electrode separated by a dielectric barrier, and wherein an end of the dielectric barrier and an inlet of the mass analyzer are electrically coupled to a ground.
A non-transitory computer-readable storage medium having embodied thereon a program, the program being executable by a processor to perform a method for multimodal ionization, the method comprising:
- receiving an analyte;
- ionizing some molecules of the analyte using a first ionization method and a first ionization source to produce first ions;
- ionizing other molecules of the analyte using a second ionization method and a second ionization source to produce second ions;
- and
- providing the first and second ions to a mass analyzer, wherein the second ionization source comprises a counter electrode and a high-voltage electrode separated by a dielectric barrier, and wherein an end of the dielectric barrier and an inlet of the mass analyzer are electrically coupled to a ground.
Dependencies are inferred from the claim text.