US 11,873,517 B2 · Candida tropicalis strain having improved tolerance to the cytotoxicity of substrates, and method for producing dicarboxylic acid using same

Abstract

The present invention relates to a Candida tropicalis cell line, which comprises a mutant gene, having improved tolerance for cytotoxicity of stromal cells, and a method for producing dicarboxylic acid using the Candida tropicalis cell line. The Candida tropicalis cell line for producing dicarboxylic acid developed according to the present invention has improved tolerance for existing stromal toxicity as well as significantly improved efficiency for producing dicarboxylic acid compared to existing cell lines, thus can be used in biological production of dicarboxylic acid and is expected to have high industrial utility.

Claims7

Dependent claims

A Candida tropicalis strain comprising one or more mutated genes selected from a mutated LIP1 (lipase) gene comprising the nucleotide sequence of SEQ ID NO:

4, a mutated FAT1 (fatty acid transport) gene comprising the nucleotide sequence of SEQ ID NO:
5, and a mutated MRP1 (multidrug resistance protein) gene comprising the nucleotide sequence of SEQ ID NO:
6.

Dependencies are inferred from the claim text.

Candida tropicalis strain having improved tolerance to the cytotoxicity of substrates, and method for producing dicarboxylic acid using same

Life of this patent

Candida tropicalis strain having improved tolerance to the cytotoxicity of substrates, and method for producing dicarboxylic acid using same

Life of this patent

Abstract

Claims7