Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA

A method for treating a subject having excessive urinary excretion of oxalate, the method comprising:

• administering to the subject in need thereof an effective amount of a nucleic acid comprising a first strand and a second strand forming a duplex structure, wherein the first strand is 21 nucleotides in length and the second strand is 23 nucleotides in length, wherein the second strand is 100% complementary with the sequence as set forth in SEQ ID NO:
• 1823, wherein the second strand has a 3′ overhang of 2 nucleotides in length, wherein a GalNac moiety is conjugated to the 3′ terminal nucleotide of the first strand, and wherein administration of the nucleic acid to the subject results in a reduction of HAO1 mRNA levels in the subject.