Synthetic polymers and crosslinked hydrogel systems
AssigneeMcMaster University
InventorsSarah Alison Stewart, Harald Donald Helmut Stover, Michael Bradley Coulson
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Abstract
A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized back-bone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having bio-medical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.
Claims15
A crosslinked hydrogel comprising a first side-chain functionalized backbone polymer functionalized with an activated alkene, which is a vinylsulfone, acrylate, methacrylate or an alkynyl group, crosslinked with a free or protected thiol-containing compound that is a polar, water-soluble compound comprising two or more thiol groups or a second side-chain functionalized backbone polymer functionalized with an amine-containing crosslinkable compound comprising a thiopyridine, a dithiocarbamate or a thioester.
Dependencies are inferred from the claim text.