Compositions and methods for treating alzheimer's disease
AssigneeGenEros Biopharma Ltd.
InventorsXin-Yuan Fu, Yi Zhou
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Abstract
Disclosed are methods for treating or preventing or delaying outset of Alzheimer's disease (AD) in a subject by targeting the novel pathway STAT1-CH25H in AD pathogenesis, specifically by administering to the subject a pharmaceutically effective amount of a STAT1 inhibitor, a CH25H inhibitor, or a 25-OHC inhibitor, for example, a 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor such as simvastatin.
Claims6
A method of treating Alzheimer's disease (AD) in a subject, the method comprising administering to the subject a pharmaceutically effective amount of a cholesterol 25-hydroxylase (CH25H inhibitor, wherein the CH25H inhibitor is a CRISPR-Cas9 or CRISPR-Cpf1 system targeting the CH25H gene.
Dependencies are inferred from the claim text.