Inhibitors for soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH)

A method for inhibiting a soluble epoxide hydrolase and fatty acid amide hydrolase, the method comprising contacting the soluble epoxide hydrolase and fatty acid amide hydrolase with a therapeutically effective amount of a compound having Formula II:

• or a pharmaceutically acceptable salt or isomer thereof, thereby inhibiting the soluble epoxide hydrolase and fatty acid amide hydrolase,
• wherein
• each R1 is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, hydroxy, C1-6 hydroxyalkyl, halogen, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, —CN, —C(O)R1a, —C(O)OR1a, —OC(O)R1a, —C(O)N(R1a)(R1b), —N(R1b)C(O)R1a, —C(O)N(R1a)CH2C(O)OR1b, —N(R1a)(R1b), —S(O)2R1a, —S(O)2N(R1a)(R1b), —N(R1b)S(O)2R1a, C3-8 cycloalkyl, C5-10 heterocycloalkyl, C6-12 aryl and C5-12 heteroaryl;
• R1a is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, and C1-6 alkyl-C6-12 aryl;
• R1b is selected from the group consisting of hydrogen and C1-6 alkyl;
• R2 is selected from the group consisting of C3-8 cycloalkyl, C3-10 heterocycloalkyl, C6-12 aryl, and C5-12 heteroaryl, optionally substituted with 1 to 2 Ra groups;
• each R2a is independently selected from the group consisting of hydrogen, C1-6 alkyl, halogen, C1-6 haloalkyl, C1-6 alkoxy, and C1-6 haloalkoxy;
• L1 is selected from the group consisting of C1-6 alkylene, C3-8 cycloalkylene, C3-10 heterocycloalkylene, C6-12 arylene, and C5-12 heteroarylene;
• R3 is selected from the group consisting of hydrogen and C1-6 alkyl, or is combined with L1 and the nitrogen to which they are attached to form a C5-8 heterocycloalkyl having 1 to 2 additional heteroatoms each independently selected from N, O and S;
• X is selected from the group consisting of CH and N;
• and
• subscript n is an integer from 1 to 4.