US 11,873,265 B2 · Method for preparing benzyl amine compound

Abstract

Disclosed is a method for preparing a benzyl amine compound, i.e., synthesizing a benzyl amine compound by means of an oxidation reaction between a methylbenzene/ethylbenzene compound and arylamine by using an ionic iron (III) complex containing 1,3-di-tert-butylimidazolium cation and having a molecular formula of [(RNCHCHNR)CH][FeBr4] (R being tert-butyl) and di-t-butyl peroxide as an oxidant. The present invention is not only applicable to a methylbenzene compound containing a benzylic primary carbon-hydrogen bond but also applicable to an ethylbenzene compound containing a benzylic secondary carbon-hydrogen bond, and therefore is widely applicable. This is the first case where the preparation of a benzyl amine compound by means of an oxidation reaction between a methylbenzene/ethylbenzene compound and arylamine is implemented by an iron catalyst.

Claims5

Dependent claims

A method for preparing a benzylamine compound comprising:

adding an aryl compound, an arylamine, an oxidizing agent, and a catalyst to form a reaction mixture;
and
conducting a reaction by heating the reaction mixture to obtain the benzylamine compound,
wherein:
the benzylamine compound has the following structure:
the aryl compound has the following structure:
the arylamine has the following structure:
the oxidizing agent is di-tert-butyl peroxide;
the catalyst is an ionic iron (III) complex having the following structure:
and
R is hydrogen or methyl;
R1 is cyano, nitro, trifluoromethyl or acetyl;
and R2 is hydrogen or methyl;
and Ar is phenyl, p-tert-butylphenyl, o-methylphenyl, mesitylphenyl, p-chlorophenyl, o-chlorophenyl, naphthyl, or thienyl.

11 more elements

Dependencies are inferred from the claim text.

Method for preparing benzyl amine compound

Life of this patent

Method for preparing benzyl amine compound

Life of this patent

Abstract

Claims5