Method for treating osteoarthritis
AssigneeHisamitsu Pharmaceutical Co., Inc.
InventorsHiroyuki Sato, Hirochika Takano
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Abstract
Disclosed is a method for treating osteoarthritis comprising a step of administering a patch to a patient. The patch comprises a backing layer and an adhesive layer laminated on the backing layer, the adhesive layer comprises an adhesive base, diclofenac sodium, dimethyl sulfoxide, and an organic acid, and a content of the organic acid is 6 mass % to 8 mass % with respect to a total mass of the adhesive layer. The patch is applied to an affected part once a day, and a dose of diclofenac sodium per administration is 70 mg to 150 mg.
Claims50
A method for treating osteoarthritis, the method comprising:
- a step of administering a patch to a patient,
- wherein the patch comprises a backing layer and an adhesive layer laminated on the backing layer,
- wherein the adhesive layer comprises an adhesive base, diclofenac sodium, dimethyl sulfoxide, and one or more organic acids,
- wherein a content of the organic acid is 6 mass % to 8 mass % with respect to a total mass of the adhesive layer,
- wherein the patch is applied to an affected part of the patient once a day,
- wherein a dose of diclofenac sodium per administration is 70 mg to 150 mg, and
- wherein the patch comprises a styrene-isoprene-styrene block copolymer and polyisobutylene as the adhesive base, and wherein the patch shows an amount of diclofenac released of 13 mg to 16 mg during a single dose and a release rate of diclofenac of 8.6% to 10.7%.
A method for treating osteoarthritis, the method comprising:
- a step of administering a patch to a patient,
- wherein the patch comprises a backing layer and an adhesive layer laminated on the backing layer,
- wherein the adhesive layer comprises an adhesive base, diclofenac sodium, dimethyl sulfoxide, and one or more organic acids,
- wherein a content of the organic acid is 6 mass % to 8 mass % with respect to a total mass of the adhesive layer,
- wherein the patch is applied to an affected part of the patient once a day,
- wherein a dose of diclofenac sodium per administration is 70 mg to 150 mg, and
- wherein the patch comprises an alicyclic saturated hydrocarbon resin and a hydrogenated rosin glycerin ester in the adhesive layer, and wherein the patch shows an amount of diclofenac released of 13 mg to 16 mg during a single dose and a release rate of diclofenac of 8.6% to 10.7%.
A method for treating osteoarthritis, the method comprising:
- a step of administering a patch to a patient,
- wherein the patch comprises a backing layer and an adhesive layer laminated on the backing layer,
- wherein the adhesive layer comprises an adhesive base, diclofenac sodium, dimethyl sulfoxide, and one or more organic acids,
- wherein a content of the organic acid is 6 mass % to 8 mass % with respect to a total mass of the adhesive layer,
- wherein the patch is applied to an affected part of the patient once a day,
- wherein a dose of diclofenac sodium per administration is 70 mg to 150 mg, and
- wherein the patch comprises liquid paraffin in the adhesive layer, and wherein the patch shows an amount of diclofenac released of 13 mg to 16 mg during a single dose and a release rate of diclofenac of 8.6% to 10.7%.
Dependencies are inferred from the claim text.