Patches for localized use

A device comprising a patch comprising:

• (i) a substrate, wherein the substrate is selected from the group consisting of ethane-acetic acid ethenyl ester, polyvinyl alcohol, ethyl cellulose, Polylactic acid, poly-ε-caprolactone (PCL) film and triglycidylamine;
• (ii) an adhesive on the substrate, wherein the adhesive is selected from the group consisting of an epoxyamine, methyl acrylate, ethyl acrylate, ethyl methacrylate, methyl methacrylate, n-butyl acrylate, n-butyl methacrylate, n-pentyl acrylate, n-hexyl acrylate, n-heptyl acrylate, and n-octyl acrylate, and a branched (meth)acrylic isomer selected from i-butyl acrylate, i-butyl methacrylate, n-butyl methacrylate, 2-ethylhexyl acrylate, stearyl methacrylate or isooctyl acrylate;
• (iii) a pocket under the substrate prefilled with a first material and a second material, wherein the first material is a combination of penetration enhancer and dye;
• wherein the penetration enhancer is selected from the group consisting of ethanol, isopropyl alcohol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyl dodecanol, oleyl alcohol;
• (iv) an opening in the substrate, and
• (v) a flap, wherein the flap covers the opening and is different than the substrate, and is configured for the introduction of materials in the patch;
• and
• wherein the patch is configured to:
• (a) attach to a skin via the adhesive to form the pocket between the patch and a skin, wherein the adhesive circumscribes the pocket,
• (b) allow introduction of a second material into the pocket through the opening, and
• (c) hold the first material and the second material within the pocket;
• wherein the first material is configured to activate under a specific condition by reacting the first material with the second material;
• wherein the device is configured to image a portion of the skin on which the patch is placed.