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US 11,866,752 B2Granted
Cysteine polysulfidation and mitochondrial bioenergetics regulated by cysteinyl-tRNA synthetase
AssigneesBio-Xcelerator, Inc., Tohoku University
InventorTakaaki Akaike
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Abstract
A method of synthesize cysteine hydropersulfide (CysSSH) includes taking a substrate L-cysteine, and performing a reaction catalyzed by cysteinyl-tRNA synthetases (CARSs).
Claims4
A method of synthesizing cysteine hydropersulfide (CysSSH) in vitro, comprising:
- providing a L-cysteine substrate;
- performing a reaction catalyzed by cysteinyl-tRNA synthetases (CARSs) in HEPES buffer in the absence of ATP and tRNA to synthesize said cysteine hydropersulfide (CysSSH).
Dependencies are inferred from the claim text.