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US 11,866,462 B2Granted
Recombinant adeno-associated viral vectors
AssigneeOregon Health & Science University
InventorsHiroyuki Nakai, Kei Adachi
Life of this patent
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Abstract
Disclosed are adeno-associated viral vectors and plasmids encoding the same. Also disclosed are methods of using adeno-associated viral vectors to deliver a protein of interest to the subject. The disclosed vectors have phenotypes including but not limited to increased retention in the blood of a subject, avoidance of the liver, and transduction of the brain and other tissues.
Claims7
A recombinant adeno-associated virus (rAAV) comprising a capsid protein, wherein the capsid protein comprises the amino acid sequence of SEQ ID NO:
- 15, and wherein said capsid protein comprises the mutations:
- E546Q, S547G, A548T, A550R, S551D, T553V, T554D, L555A, N557K, D562N, and A568T.
Dependencies are inferred from the claim text.