Broad-spectrum anti-infective peptides
AssigneeNanyang Technological University
InventorsNam-Joon Cho, Joshua Alexander Jackman
Life of this patent
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Abstract
Provided herein are anti-infective peptides and uses thereof. Such anti-infective peptides are useful against bacteria and viruses. Also provided herein are compositions comprising said anti-infective peptides.
Claims19
A peptide of 16 to 26 amino acid residues in length comprising an amino acid sequence selected from the group consisting of:
- SGSWLRDVWTWLQSKL (SEQ ID NO:1), GSSWLRDVWTWLQSKL (SEQ ID NO:2), GSSWLRDVWTWLQSAL (SEQ ID NO:3), GSSWLRDVWTKLQSWL (SEQ ID NO:4), and GSSWLRDIWTALQSWL (SEQ ID NO:6).
A peptide of 16 amino acid residues in length, consisting of an amino acid sequence selected from the group consisting of:
- SGSWLRDVWTWLQSKL (SEQ ID NO:1), GSSWLRDVWTWLQSKL (SEQ ID NO:2), GSSWLRDVWTWLQSAL (SEQ ID NO:3), GSSWLRDVWTKLQSWL (SEQ ID NO:4), and GSSWLRDIWTALQSWL (SEQ ID NO:6).
A composition comprising:
- (a) (i) a peptide of 16 to 26 amino acid residues in length comprising an amino acid sequence selected from the group consisting of:
- SGSWLRDVWTWLQSKL (SEQ ID NO:1), GSSWLRDVWTWLQSKL (SEQ ID NO:2), GSSWLRDVWTWLQSAL (SEQ ID NO:3), GSSWLRDVWTKLQSWL (SEQ ID NO:4), and GSSWLRDIWTALQSWL (SEQ ID NO:6), and
- (ii) a carrier;
- or
- (b) (i) a pegylated peptide of 16 to 26 amino acid residues in length comprising an amino acid sequence selected from the group consisting of:
- SGSWLRDVWTWLQSKL (SEQ ID NO:1), GSSWLRDVWTWLQSKL (SEQ ID NO:2), GSSWLRDVWTWLQSAL (SEQ ID NO:3), GSSWLRDVWTKLQSWL (SEQ ID NO:4), and GSSWLRDIWTALQSWL (SEQ ID NO:6), and
- (ii) a carrier.
An in vitro or ex vivo method for inhibiting growth, replication, or infectivity of a microorganism, comprising contacting the microorganism with an effective amount of a composition comprising:
- (a) (i) a peptide of 16 to 26 amino acid residues in length comprising an amino acid sequence selected from the group consisting of:
- SGSWLRDVWTWLQSKL (SEQ ID NO:1), GSSWLRDVWTWLQSKL (SEQ ID NO:2), GSSWLRDVWTWLQSAL (SEQ ID NO:3), GSSWLRDVWTKLQSWL (SEQ ID NO:4), and GSSWLRDIWTALQSWL (SEQ ID NO:6), and
- (ii) a carrier;
- or
- (b) (i) a pegylated peptide of 16 to 26 amino acid residues in length comprising an amino acid sequence selected from the group consisting of:
- SGSWLRDVWTWLQSKL (SEQ ID NO:1), GSSWLRDVWTWLQSKL (SEQ ID NO:2), GSSWLRDVWTWLQSAL (SEQ ID NO:3), GSSWLRDVWTKLQSWL (SEQ ID NO:4), and GSSWLRDIWTALQSWL (SEQ ID NO:6), and
- (ii) a carrier.
A method for disinfecting an inanimate object or biological material, comprising contacting the inanimate object with a composition comprising:
- (a) (i) a peptide of 16 to 26 amino acid residues in length comprising an amino acid sequence selected from the group consisting of:
- SGSWLRDVWTWLQSKL (SEQ ID NO:1), GSSWLRDVWTWLQSKL (SEQ ID NO:2), GSSWLRDVWTWLQSAL (SEQ ID NO:3), GSSWLRDVWTKLQSWL (SEQ ID NO:4), and GSSWLRDIWTALQSWL (SEQ ID NO:6), and
- (ii) a carrier, or
- (b) (i) a pegylated peptide of 16 to 26 amino acid residues in length comprising an amino acid sequence selected from the group consisting of:
- SGSWLRDVWTWLQSKL (SEQ ID NO:1), GSSWLRDVWTWLQSKL (SEQ ID NO:2), GSSWLRDVWTWLQSAL (SEQ ID NO:3), GSSWLRDVWTKLQSWL (SEQ ID NO:4), and GSSWLRDIWTALQSWL (SEQ ID NO:6), and
- (ii) a carrier.
A method for disinfecting an inanimate object or biological material, comprising contacting the inanimate object with a wipe containing a peptide of 16 to 26 amino acid residues in length comprising an amino acid sequence selected from the group consisting of:
- SGSWLRDVWTWLQSKL (SEQ ID NO:1), GSSWLRDVWTWLQSKL (SEQ ID NO:2), GSSWLRDVWTWLQSAL (SEQ ID NO:3), GSSWLRDVWTKLQSWL (SEQ ID NO:4), and GSSWLRDIWTALQSWL (SEQ ID NO:6).
Dependencies are inferred from the claim text.