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US 11,865,536 B2Granted
Human lymphoid tissue-on-chip
AssigneePresident and Fellows of Harvard College
InventorsGirija Goyal, Donald E. Ingber
Life of this patent
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Abstract
An organ-on-a-chip microfluidic device is disclosed that mimics a human lymph node and/or human lymphoid tissue. The device can include cells from human blood and lymphatic tissue, include an extracellular matrix for the development of immune system components, and provide for the perfusion of fluids and solids resembling blood and lymphatic fluid within micrometer sized channels.
Claims10
A microfluidic device comprising:
- a body comprising a first microchannel, a first chamber and a second chamber, the first microchannel having an inlet and an outlet to an exterior of the body, the first chamber being in fluidic communication with the first microchannel and comprising a first matrix comprising B lymphocytes, and the second chamber comprising a second matrix comprising T lymphocytes.
A method, comprising
- a) providing a microfluidic device comprising a body comprising a first microchannel, a first chamber and a second chamber, the first microchannel having an inlet and an outlet to an exterior of the body, the first chamber being in fluidic communication with the first microchannel;
- b) providing a first matrix comprising T lymphocytes in said first chamber, and
- c) providing a second matrix comprising B lymphocytes in said second chamber.
Dependencies are inferred from the claim text.