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US 11,865,224 B2Granted
Delivery systems based on hydrogel compositions and methods thereof
AssigneeUniversity of Massachusetts
InventorsJie Song, Yu Tan, Henry Huang
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Abstract
The invention provides a novel, versatile degradable hydrogel composition, and methods thereof, with precisely tunable stiffness, plasticity (e.g., degree of covalent vs. physical crosslinks) and predictive disintegration rates degradation, allowing controlled disintegration and release of therapeutic cells or pharmaceuticals and/or in vitro 3D cell expansion.
Claims12
A method for delivering a biologically active payload, comprising,
- placing in a subject in need thereof a device or implant, wherein the device or implant comprises a hydrogel comprising a 3-dimensional crosslinking network of a combination of covalent crosslinking (CX) and non-covalent crosslinking (NCX) of hydrophilic branched polymers,
- wherein the hydrophilic branched polymers are star-branched with at least 3 arms;
- and
- causing a controlled release of the biologically active payload.
1 more element
Dependencies are inferred from the claim text.