Back to results
US 11,865,205 B2Granted
Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
AssigneeMedincell
InventorsGeorges Gaudriault, Sylvestre Grizot, Mark Hurtig, Matthew Shive
Life of this patent
Estimating the term…
Abstract
A method of targeting to the synovial tissue biodegradable drug delivery compositions or morselizing biodegradable drug delivery compositions are described. The biodegradable drug composition comprises a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as at least one pharmaceutically active principle is disclosed.
Claims19
A method for morselizing a biodegradable drug delivery composition comprising at least one pharmaceutically active principle comprising:
- (1) formulating a biodegradable drug composition comprising
- (a) a biodegradable triblock copolymer having the formula:
- PLAv-PEGw-PLAx
- wherein v and x are the number of repeat units ranging from 24 to 682 and w is the number of repeat units ranging from 4 to 273 and v=x or v≠x;
- (b) a biodegradable diblock copolymer having the formula:
- mPEGy-PLAz
- wherein y and z are the number of repeat units with y ranging from 3 to 45 and z ranging from 7 to 327, wherein the polyethylene glycol chain in the triblock and/or the diblock copolymer is 2 kDa and
- wherein the ratio of the biodegradable triblock copolymer of (a) and the biodegradable diblock copolymer of (b) is 3:2 to 1:19 in said biodegradable drug composition and
- (c) at least one pharmaceutically active principle;
- (2) administering said formulated biodegradable drug delivery composition in at least one joint of a patient, such that it is contained within the articulating joint capsule.
7 more elements
Dependencies are inferred from the claim text.