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US 11,865,194 B2Granted
Benzene ring-containing glucose derivative and use thereof
AssigneeBeijing Normal University
InventorsJunbo Zhang, Qianqian Gan, Qianna Wang, Xuran Zhang, Qing Ruan, Yuhao Jiang, Xuebin Wang, Zhigang Tang, Jie Lu, Zhanbin Zhang
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Abstract
Disclosed herein is a benzene ring-containing glucose derivative of formula (I): where R1 is each independently and R2 is hydrogen. This application also provides a radioactive drug, including a complex formed by the benzene ring-containing glucose derivative and a radionuclide. Use of the benzene ring-containing glucose derivative in the tumor treatment and diagnosis is further provided.
Claims5
A benzene ring-containing glucose derivative of formula (I):
- wherein one or two R1 are located on a benzene ring in formula (I);
- the one or two R1 are each independently
- when there is one R1, R1 is on 3-position or 4-position of the benzene ring in formula (I);
- when there are two R1, the two R1 are on 3-position and 4-position of the benzene ring, respectively;
- R3 is hydrogen;
- m is 0 or 1;
- and represents chemical bonding between R1 and the benzene ring in formula (I);
- R2 is hydrogen;
- n is 0, 1 or 2;
- and
- when m=0 and n=1, R1 is not on the 4-position of the benzene ring.
8 more elements
A radioactive drug, comprising:
- a complex formed by a benzene ring-containing glucose derivative and a radionuclide;
- wherein:
- the radionuclide is 99mTc;
- the benzene ring-containing glucose derivative is represented by formula (I):
- and
- the complex is represented by formula (II):
- wherein in formula (I) and formula (II):
- one or two R1 are located on each of benzene rings;
- the one or two R1 are each independently
- wherein when there is one R1, R1 is on 3-position or 4-position of each of the benzene rings;
- when there are two R1, the two R1 are on 3-position and 4-position of each of the benzene rings, respectively;
- R3 is hydrogen:
- m is 0 or 1;
- and represents chemical bonding between R1 and each of the benzene rings;
- R2 is hydrogen;
- n is 0, 1 or 2;
- and
- when m=0 and n=1, R1 is not on the 4-position of each of the benzene rings.
15 more elements
Dependencies are inferred from the claim text.