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US 11,865,150 B2Granted
Materials and methods for treating cancer
AssigneeMayo Foundation for Medical Education and Research
InventorsEvanthia Galanis, S. Keith Anderson, Cheyne B. Kurokawa, Ianko D. Iankov
Life of this patent
Estimating the term…
Abstract
This document provides methods and materials involved in treating cancer. For example, methods and materials for using an inhibitor of UFM1 activity or expression and/or an inhibitor of UFL1 activity or expression to reduce a cancer cell's ability to carry out a DDR, thereby increasing the sensitivity of cancer cells to treatment with a DNA damaging therapy such as radiation or chemotherapy, are provided.
Claims10
A method for treating cancer in a mammal, wherein said method comprises:
- (a) identifying said mammal as having cancer cells that have a virotherapy permissive interferon (IFN)-stimulated gene (ISG) signature, wherein said virotherapy permissive ISG signature comprises a decreased level of expression of at least 6 ISGs selected from the group consisting of HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, IFI27, IFI35, IFI6, IFIT1, IFIT3, IRF1, IRF2, IRF9, ISG15, MX1, MX2, OAS1, OAS2, OAS3, OASL, SOCS1, and STAT2, wherein said virotherapy permissive ISG signature indicates that said cancer cells are responsive to treatment with an oncolytic virus;
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- (b) administering said oncolytic virus to said mammal under conditions wherein the number of cancer cells within said mammal is reduced.
Dependencies are inferred from the claim text.