US 11,865,083 B2Granted

Rapid method of generating live attenuated vaccines

AssigneeNational University of Singapore

InventorsEng Eong Ooi, Kenneth Goh, Swee Sen Kwek, Choon Kit Tang

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Abstract

The present invention relates to a method of generating a live attenuated vaccine. The present invention also relates to a live attenuated vaccine produced according to the method of the invention.

Claims17

Dependent claims

A vaccine comprising a nucleic acid sequence encoding the genome of a maladapted Zika virus, wherein the nucleic acid sequence comprises a sequence selected from the group consisting of SEQ NO:

39, SEQ ID NO:
40, SEQ ID NO:
41, and SEQ ID NO:
42.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 17/249,329Filed 26 Feb 2021 · continuation
Priority: SG 10201602980W14 Apr 2016
Published: US 2021/0187094 A124 Jun 2021
Granted: 9 Jan 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
A61K 2039/5254
Virus: avirulent or attenuated
C12N 2770/24121
Flavivirus, e.g. yellow fever virus, dengue, JEV: viruses as such, e.g. new isolates, mutants or their genomic sequences

Family

PCT/SG2017/050211Parent of this continuation · filed 13 Apr 2017
US 2021/0187094 A1Pre-grant publication · published 24 Jun 2021
Application16/093,262Parent of this continuation
US 2019/0125855 A1Published application
US 11,865,083 B2This patent

From the US filing history. Foreign family members aren’t listed.

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