Oncolytic viral delivery of therapeutic polypeptides
AssigneeVirogin Biotech Canada Ltd
InventorsMitchell H. Finer, Luke Evnin
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Abstract
Described herein are oncolytic viruses comprising one or more nucleic acids encoding an engager molecule. In some embodiments, the oncolytic viruses comprise one or more nucleic acids encoding an engager molecule and one or more therapeutic molecules. Pharmaceutical compositions containing the oncolytic virus and methods of treating cancer using the oncolytic viruses are further provided herein.
Claims14
An oncolytic virus comprising a first recombinant nucleic acid encoding an engager polypeptide comprising an effector domain specific for an antigen expressed on an effector cell and a targeting domain specific for an antigen expressed on a target cell, wherein the antigen expressed on the target cell is fibroblast activation protein (FAP), wherein the antigen expressed on the effector cell is CD3, and wherein the engager polypeptide comprises a polypeptide sequence that is at least 90% identical to SEQ ID NO:
- 75.
Dependencies are inferred from the claim text.