Primary packaging containers for pharmaceutical substances and methods of making

A primary packaging container for receiving a pharmaceutical product, comprising:

• a hollow body having an opening, the hollow body comprises a cycloolefin polymer or a cycloolefin copolymer;
• and
• a closure having a puncturing region, the closure closing the opening with the puncturing region at the opening, the puncturing region being configured to allow introduction of a cannula into the hollow body and resealing the hollow body upon withdrawal of the cannula,
• wherein the closure comprises a normal elastomer that connects the closure and the hollow body together so that the closure and the hollow body are not separable in a non-destructive manner and comprises a thermoplastic elastomer layer over the normal elastomer, and
• wherein the hollow body and the normal elastomer are injection moulded to one another.

An apparatus comprising:

• a hollow body having an opening, the hollow body comprising a cycloolefin polymer or a cycloolefin copolymer;
• a single dose of a therapeutic substance and/or a diagnostic substance in the hollow body;
• and
• a closure being made of a normal elastomer and a thermoplastic elastomer layer over the normal elastomer defining a continuous puncture region therethrough, the closure closing the opening with the puncturing region at the opening, the puncturing region configured to allow introduction of a cannula into the hollow body, the normal elastomer being connected to the hollow body so that the normal elastomer and hollow body are inseparable from one another without damage to the normal elastomer and/or the hollow body.

A primary packaging container for receiving a pharmaceutical product, comprising:

• a hollow body having an opening, the hollow body comprises a cycloolefin polymer or a cycloolefin copolymer;
• and
• a closure having a puncturing region, the closure closing the opening with the puncturing region at the opening, the puncturing region being configured to allow introduction of a cannula into the hollow body and resealing the hollow body upon withdrawal of the cannula,
• wherein the closure comprises an elastomer that connects the closure and the hollow body together so that the closure and the hollow body are not separable in a non-destructive manner,
• wherein the hollow body comprises an outer side, wherein the outer side lacks a flanged rim at the opening and has at least one form-fitting element that is configured for receipt in a device, and
• wherein the elastomer of the closure is a normal elastomer and the closure further comprises a layer of thermoplastic elastomer over the normal elastomer.