Composition comprising low temperature water extract of hibiscus manihot for anti-obesity

Abstract

Provides is an anti-obesity composition, including a low-temperature Geumhwagyu extract as an active ingredient. The extract was obtained by adding Geumhwagyu to low-temperature water at 4 to 50° C. and extracting for 1 to 20 hours. The extract increases energy consumption through an increase in expression of adipose triglyceride lipase (ATGL) and hormone-sensitivity lipase (HSL), lipolysis through inhibition of expression of perilipin-1, and thermal generation through an increase in expression of uncoupling protein (UCP). In addition, the extract improves energy metabolism by increasing the expression of phospho-AMP-activated protein kinase (AMPK), inhibits lipid formation and accumulation of adipocytes by inhibiting cell growth of mature adipocytes, and shows anti-obesity activity, thereby being easily used as a pharmaceutical composition and healthy functional food for obesity.

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