Functionalized calibrants for spectrometry and chromatography
AssigneePolymer Factory Sweden AB
InventorScott M. Grayson
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Abstract
Calibrants and methods of making the same include using mixtures of multifunctional core compounds or multifunctional dendrimers that are functionalized to yield a set of discrete compounds which cover a range of collisional cross sections (CCSs) for calibrating ion mobility and variation in molecular weight to calibrate the mass to charge (m/z) measurements of mass spectrometry, as well as for calibrating tandem instruments that measure both dimensions. Methods of using the calibrants are also disclosed, such as in mass spectrometry.
Claims20
A composition comprising at least two calibrant compounds or salts thereof, or cationic complexes thereof, or anionic complexes thereof, wherein the at least two calibrant compounds or the salts thereof or the cationic complexes thereof, or the anionic complexes thereof comprise an alcohol functionalized core, and peripheral functionalities, wherein the at least two cores with at least one alcohol functionality is selected from the group consisting of:
- and wherein the peripheral functionalities are esters prepared by coupling the alcohol functionalities of the cores with a carboxylic acid, or an activated ester, or an activated carboxylic acid derivative having a chemical structure of Formula II:
- wherein m=1-30.
Dependencies are inferred from the claim text.