Microfluidic device and method for quantifying contact lens deposition
AssigneeJohnson & Johnson Vision Care, Inc.
InventorsZhenyu Li, Bailin Liang
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods for quantifying contact lens deposition. An example method may comprise disposing a contact lens sample in a fluid well. The example method may comprise disposing a volume of tear fluid in the well with the contact lens sample. The example method may comprise capturing pre-rinse images of the contact lens sample. The example method may comprise rinsing the contact lens sample. The example method may comprise capturing post-rinse images of the contact lens after the rinsing. The example method may comprise determining, using one or more of the tear images or the post-rinse images, a deposition metric. The example method may comprise outputting the deposition metric.
Claims79
A method for quantifying contact lens deposition using a microfluidic chip comprising a well in fluid communication with a fluid conduit, wherein the fluid conduit is in selective communication with a fluid inlet and a fluid outlet to control passage of fluid through the fluid conduit and into the well, the method comprising:
- disposing a contact lens sample in the well of the microfluidic chip;
- disposing a first volume of first fluid in the well with the contact lens sample;
- capturing first images of the contact lens sample;
- causing evaporation of at least a portion of the first volume of the first fluid;
- disposing a second volume of second fluid in the well with the contact lens sample;
- causing evaporation of at least a portion of the second volume of the second fluid;
- disposing the microfluidic chip in a humidity chamber for a time period;
- capturing second images of the contact lens sample after the time period has expired;
- rinsing the contact lens sample with a third fluid;
- capturing third images of the contact lens after the rinsing;
- determining, using one or more of the first images, the second images, or the third images, a deposition metric;
- and
- outputting the deposition metric.
A method for quantifying contact lens deposition using a microfluidic chip comprising a well in fluid communication with a fluid conduit, wherein the fluid conduit is in selective communication with a fluid inlet and a fluid outlet to control passage of fluid through the fluid conduit and into the well, the method comprising:
- disposing a contact lens sample in the well of the microfluidic chip;
- capturing a pre-tear image of the contact lens sample;
- disposing a volume of tear fluid in the well with the contact lens sample;
- capturing a tear image of the contact lens sample;
- rinsing the contact lens sample;
- capturing a post-rinse image of the contact lens after the rinsing;
- determining, using one or more of the pre-tear images, the tear images, or the post-rinse images, a deposition metric;
- and
- outputting the deposition metric.
A method for quantifying contact lens deposition using a microfluidic chip comprising a well in fluid communication with a fluid conduit, wherein the fluid conduit is in selective communication with a fluid inlet and a fluid outlet to control passage of fluid through the fluid conduit and into the well, the method comprising:
- disposing a contact lens sample in the well of the microfluidic chip;
- disposing a volume of tear fluid in the well with the contact lens sample;
- capturing tear images of the contact lens sample;
- rinsing the contact lens sample;
- capturing post-rinse images of the contact lens after the rinsing;
- determining, using one or more of the tear images or the post-rinse images, a deposition metric;
- and
- outputting the deposition metric.
A method for quantifying contact lens deposition, the method comprising:
- disposing a contact lens sample in a fluid well;
- disposing a volume of tear fluid in the well with the contact lens sample;
- capturing pre-rinse images of the contact lens sample;
- rinsing the contact lens sample;
- capturing post-rinse images of the contact lens after the rinsing;
- determining, using one or more of the pre-rinse images or the post-rinse images, a deposition metric;
- and
- outputting the deposition metric.
A method for evaluating a contact lens wearer's compatibility with a lens material, the method comprising:
- exposing a contact lens sample to a volume of tear fluid from the wearer;
- capturing pre-rinse data of the contact lens sample;
- rinsing the contact lens sample;
- capturing post-rinse data of the contact lens sample after the rinsing;
- and
- comparing the pre-rinse data with the post-rinse data.
Dependencies are inferred from the claim text.