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US 11,860,161 B2Granted
Detection and treatment of autoimmune disorders
AssigneeSeattle Children's Hospital
InventorsNeelufar Mozaffarian, Anne M. Stevens
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Abstract
Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.
Claims10
A method of distinguishing between the presence of systemic lupus erythematosus (SLE) and a bacterial or viral infection comprising:
- (a) obtaining a blood sample from a human subject;
- (b) contacting the blood sample with a detectably labeled antibody specific for PD-L1 and at least one antibody specific for a cell surface marker on a monocyte or dendritic cell;
- (c) detecting the presence or absence of monocytes or dendritic cells;
- and
- (d) determining the amount of PD-L1 in a blood sample containing monocytes or dendritic cells, wherein a PD-L1 amount from monocytes or dendritic cells that is lower than a control value is indicative of SLE and a PD-L1 amount from monocytes or dendritic cells that is higher than the control value is indicative of a bacterial or viral infection, wherein the control value is established based on a PD-L1 amount of one or more healthy subjects.
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Dependencies are inferred from the claim text.