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US 11,860,157 B2Granted
Polymer microfilters, devices comprising the same, methods of manufacturing the same, and uses thereof
AssigneeCreatv MicroTech, Inc.
InventorsOlga Makarova, Cha-Mei Tang, Peixuan Zhu, Shuhong Li, Daniel Adams, Platte T. Amstutz
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Abstract
A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.
Claims14
A microfilter comprising:
- a first single polymer layer formed from an epoxy-based negative photo-definable dry film, wherein the first single polymer layer has a flexibility to be disposed on a roll and unrolled;
- a plurality of first apertures formed by exposing the first single polymer layer to a UV light via an optical mask to obtain a selected shape of said apertures based on said optical mask, each of said apertures extending through the first single polymer layer having said flexibility,
- said first single polymer layer having said first apertures and said flexibility forming a freestanding unattached microfilter structure with uniform thickness and having said flexibility;
- and
- a surface on said first single polymer layer modified to be hydrophilic.
2 more elements
Dependencies are inferred from the claim text.