Determination of concentrations and amounts of perfluoroalkyl substances by LC/MS/MS
AssigneeSuffolk County Water Authority
InventorAmanda Comando
Life of this patent
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Abstract
A method and system for injecting an unconcentrated sample into a receiving LC/MS/MS system that is configured to determine a concentration of one or more PFAS analytes within the unconcentrated sample, wherein the LC/MS/MS includes ESI. The unconcentrated sample may be subjected to one or more of the following ESI conditions: i) a probe gas temperature of approximately 120° C. to approximately 180° C.; ii) a sheath gas heater setting of approximately 250° C. to approximately 400° C.; and/or iii) a sheath gas flow of approximately 8 L/min to approximately 12 L/min. The unconcentrated sample's concentration and/or an injected amount of the one or more PFAS analytes is determined.
Claims22
A method for facilitating detecting PFAS analytes in a sample comprising:
- injecting a volume of the sample into an LC/MS/MS system that is configured to detect one or more PFAS analytes of formula CnF(2n+1)—X within an unconcentrated sample;
- wherein:
- the LC/MS/MS includes ESI;
- n is 3, 4, 5, 6, 7, 8 or 9;
- and
- —X is —SO3H, —CO2H, −SO3−, or —CO2−;
- subjecting the injected volume of the sample to ESI conditions that include a sheath gas flow of approximately 8 L/min to approximately 12 L/min;
- and
- detecting one or more PFAS analytes within the sample.
A PFAS analyte detection system comprising:
- an LC/MS/MS system operable utilizing ESI and configured to:
- receive an injected volume of a sample containing one or more PFAS analytes of formula CnF(2n+1)—X;
- wherein:
- n is 3, 4, 5, 6, 7, 8 or 9;
- and
- —X is —SO3H, —CO2H, —SO3−, or —CO2−;
- subject the injected volume of the sample to ESI conditions that include a probe gas temperature of approximately 120° C. to approximately 180° C.;
- and
- detect one or more PFAS analytes within the sample.
A method for facilitating the detection of PFAS analytes in a sample comprising:
- obtaining a sample containing one or more PFAS analytes of formula CnF(2n+1)—X;
- wherein:
- n is 3, 4, 5, 6, 7, 8 or 9;
- and
- —X is —SO3H, —CO2H, —SO3, or —CO2
- receiving data representative of test results of an analysis detecting at least one of the one or more PFAS analytes of formula CnF(2n+1)—X within at least a portion of the sample, the test results comprising one or both:
- i) the concentration of the at least one PFAS analyte in the sample;
- and ii) the amount within an injected volume of the sample of the at least one PFAS analyte into an LC/MS/MS system;
- wherein:
- i) the concentration of the at least one PFAS analyte within the sample is between approximately 0.0020 μg/L and approximately 0.25 μg/L;
- and/or
- ii) the amount of the at least one PFAS analyte within the injected volume of the sample is between approximately 1.5×10−7 μg and approximately 1.9×10−5 μg;
- wherein the analysis comprised the following steps a) and b):
- a) injecting a volume of the sample into the LC/MS/MS system with ESI that is configured to detect the at least one PFAS analyte;
- and
- b) subjecting the injected volume of the sample to ESI conditions that include a sheath gas flow of approximately 8 L/min to approximately 12 L/min.
Dependencies are inferred from the claim text.