Macrocyclic modulators of disease associated protein misfolding and aggregation
AssigneeResq Biotech
InventorGeorgios Skretas
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Abstract
Aspects of the present invention disclose compounds that modulate the aggregation of amyloidogenic proteins or peptides. In some aspects, disclosed compounds modulate the aggregation of disease-associated proteins and natural β-amyloid peptides. In a preferred embodiment, the compounds can inhibit natural amyloid aggregation. Pharmaceutical compositions comprising the compounds of the embodiments, and diagnostic and treatment methods for diseases (e.g., amyloidogenic diseases) using the compounds, are also disclosed. In addition, there is provided an integrated bacterial platform for the discovery of rescuers of disease-associated protein misfolding.
Claims19
An engineered cyclic pentapeptide having an amino acid sequence NuX1X2X3X4, wherein:
- Nu is T;
- X1 is A, L, V, F, W, Y, C, S, T, D, R, P or G;
- X2 is S;
- X3 is A, L, V, F, W, Y, M, S, T, R, H or G;
- and X4 is W.
An engineered pentapeptide having an amino acid sequence NuX1X2X3X4, wherein:
- Nu is T;
- X1 is S, A, F or W;
- X2 is S;
- X3 is A, L, V, F, W, Y, M, S, T, R, H or G;
- and X4 is W.
Dependencies are inferred from the claim text.