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US 11,858,889 B2Granted
Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease
AssigneeThe Trustees of Indiana University
InventorsJaipal Singh, Kerry Fowler
Life of this patent
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Abstract
Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.
Claims4
A compound defined by the formula:
- or a pharmaceutically acceptable salt, wherein
- i) R8, R9, R10, R11, R5 and R4 are hydrogen and R6 is methyl;
- or
- ii) R8, R9, R10, R11, R6, and R5 are hydrogen and R4 is methyl;
- or
- iii) R8, R9, R10, R11, R6, and R5 are hydrogen and R4 is chloro or floro;
- or
- iv) R8, R9, R10, R11, and R6 are hydrogen, R5 is methyl and R4 is methoxy;
- or
- v) R8, R9, R10, R11, and R5 are hydrogen, R6 is methyl and R4 is hydroxy;
- or
- vi) R8, R9, R10, R11, R6, and R5 are hydrogen and R4 is 2-(morpholin-4-yl)ethoxy;
- or
- vii) R8, R9, R10, R11, R6, and R4 are hydrogen and R5 is 2-(morpholin-4-yl)ethoxy;
- or
- viii) R8, R9, R10, R11, R5, and R4 are hydrogen and R6 is 2-(morpholin-4-yl)ethoxy.
13 more elements
Dependencies are inferred from the claim text.