Method for continuously synthesizing propellane compound

A method for continuously synthesizing a propellane compound, wherein the method comprises the following step:

• using 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane or a derivative thereof as a raw material to form a ring with a lithium metal agent by a continuous reaction, so as to synthesize the propellane compound;
• the continuous reaction is carried out in a continuous stirred tank reactor;
• the continuous stirred tank reactor comprises a first-stage continuous stirred tank reactor, a second-stage continuous stirred tank reactor and a third-stage continuous stirred tank reactor which are connected in series;
• the 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane or the derivative thereof is dissolved in a first solvent to obtain solution A, and the lithium metal agent is dissolved in a second solvent to obtain solution B, and the solution A and the solution B are added to the continuous stirred tank reactor by an automatic feeding system for the continuous reaction;
• in the solution A, the molar concentration of the 1,1-dibromo-2,2-bis(chloromethyl) cyclopropane or the derivative thereof is 0.5 to 3.0 M;
• in the solution B, the molar concentration of the lithium metal agent is 1.0 M to 3.0 M;
• the feeding ratio of the solution A to the solution B is 1:2.0 to 1:3.0;
• in the first stage continuous stirred tank reactor, the reaction temperature is −51° C. to −75° C., and the reaction time is 20 to 40 min;
• in the second stage continuous stirred tank reactor, the reaction temperature is −5° C. to 5° C., and the reaction time is 30 to 60 min;
• and
• in the third stage continuous stirred tank reactor, the reaction temperature is −5° C. to 5° C., and the reaction time is 30 to 60 min;
• the 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane or a derivative thereof has the following structure:
• wherein R1 and R2 each independently are —CH3 or —C2H5.