Dimerization strategies and compounds for molecular imaging and/or radioimmunotherapy
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsDexing Zeng, Lingyi Sun, Yongkang Gai
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Abstract
The present invention provides a multivalent compound for targeted molecular imaging and/or targeted drug delivery, wherein two components or targeting molecules each interacts with one or more biomarkers on a cell. The present invention further provides a multifunctional chelator to combine the targeting molecules. The present invention also provides an in vitro high-throughput screening assay to determine the length of the spacer molecules. The present invention also relates to compounds/probes, kits and methods for use in targeted molecular imaging and/or targeted drug delivery.
Claims8
A compound for molecular imaging or therapy comprising:
- wherein A comprises a first peptide and a chelator;
- wherein B comprises a second peptide;
- wherein the chelator comprises a chelating core selected from the group consisting of NOTA, NETA, CB-TE2A, CB-TE1A1P, TETA, Pycu2A, DiAmSar, DOTA, DTPA, PCTA, and DFO;
- and
- wherein the first and the second peptide are independently selected from the group consisting of NGR, LLP2A, BBN(7-14), Tyr(3)-octreotate, DAPTA, RGD c(cNGRc), c(RGDyK), and RAD.
Dependencies are inferred from the claim text.