Nanovectors and uses
AssigneeNh Theraguix
InventorsOlivier Tillement, François Lux, Fabien Rossetti, Vu-Long Tran, Clélia Mathieu, Myleva Dahan
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Abstract
The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.
Claims24
A nanovector for the delivery of an active substance in a human being, wherein said nanovector comprises a nanoparticle on the surface of which the active substance is bonded by physisorption, said nanoparticle is a polysiloxane-based nanoparticle with a mean diameter of less than 10 nm, the active substance is chosen from organic molecules which have a molar mass of between 2% and 40% of the total molar mass of said nanoparticle, and said nanoparticle comprises:
- a. polysiloxanes, with a weight ratio of silicon of at least 8% of the total weight of the nanoparticle,
- b. a chelating agent grafted onto the nanoparticle, wherein the chelating agent which is grafted onto the nanoparticle is selected from DOTA, DTPA, EDTA, EGTA, BAPTA, NOTA, DOTAGA and DTPABA or a mixture thereof, and
- c. optionally, a metal element, said metal element being complexed to the chelating agent.
Dependencies are inferred from the claim text.