Lipo-glycopeptide cleavable derivatives and uses thereof
AssigneeInsmed Incorporated
InventorsRyan Heckler, Donna Konicek, Adam Plaunt, Vladimir Malinin, Walter Perkins
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Abstract
The present invention provides certain lipo-glycopeptide cleavable derivatives and methods for using the same for the treatment of bacterial infections, for example, pulmonary bacterial infections. The LGPC derivatives include a cleavable moiety that in certain embodiments, is designed to allow for cellular uptake and/or a more rapid clearance of the glycopeptide metabolite (i.e., the cleaved glycopeptide) from the site of administration (e.g., the lung) as compared to the uncleaved LGPC.
Claims18
A method for treating a Gram-positive pulmonary bacterial infection in a patient in need thereof, the method comprising:
- administering to the lungs of the patient via a nebulizer, dry powder inhaler (DPI) or metered dose inhaler (MDI), a composition comprising an effective amount of a compound of Formula (II), or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is —(CH2)n1—O—C(O)—(CH2)n2—CH3;
- n1 is 2;
- n2 is 12;
- R2 is OH;
- R3 is H;
- and
- R4 is H.
Dependencies are inferred from the claim text.