Oncolytic virus growth method and antitumor agent
AssigneesHisanobu Ogata, Kenzaburo Tani, Kabushiki Kaisha Yakult Honsha
InventorsHisanobu Ogata, Kenzaburo Tani
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Abstract
Provided is antitumor therapy using oncolytic viruses which exhibits an excellent antitumor effect and has reduced adverse effects. An antitumor agent, comprising a combination of an oncolytic virus and an anticancer agent selected from the group consisting of oxaliplatin, an anticancer plant alkaloid, and an antimetabolite.
Claims8
A method for enhancing an antitumor effect of a coxsackievirus, the method comprising:
- administering oxaliplatin and the coxsackievirus to a subject in need thereof.
A method for promoting proliferation of a coxsackievirus, the method comprising:
- culturing the coxsackievirus in the presence of oxaliplatin.
A method for enhancing an expression of a virus receptor of a cancer cell, the method comprising:
- administering oxaliplatin,
- wherein the virus receptor is DAF, ICAM-1, or a combination thereof.
A method for treating oxaliplatin resistant cancer, the method comprising:
- administering an antitumor agent comprising a combination of oxaliplatin and an antimetabolite and a coxsackievirus to a patient having oxaliplatin-resistant cancer.
Dependencies are inferred from the claim text.