Compounds for treating corona virus infection
AssigneeNLC Pharma Ltd
InventorDorit Arad
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Abstract
Described herein are compounds of Formula I: wherein R1-R6 are as described herein, for use in the treatment of a coronavirus infection; a method of inhibiting a coronavirus 3CL protease, by contacting the 3CL protease with a compound of Formula I; as well as methods pharmaceutical composition comprising a compound of Formula I and at least one phospholipid, wherein a weight ratio of the phospholipid(s) to the compound in the composition is in a range of from 10:1 to 1:10. Further described herein is a method of treating a coronavirus infection in a subject in need thereof, by administering to the subject at least one compound that exhibits at least two of: inhibition of an activity of a 3CL protease of the coronavirus; inhibition of inflammation in the subject; and inhibition of autophagy in the subject.
Claims15
A method of treating a coronavirus infection in a subject in need thereof, the method comprising administering to the subject a compound represented by Formula I:
- wherein R1-R6 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, sulfonate, sulfate, cyano, nitro, azide, phosphonyl, phosphinyl, carbonyl, thiocarbonyl, a urea group, a thiourea group, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, S-thiocarbamyl, C-amido, N-amido, C-carboxy, O-carboxy, sulfonamido, guanyl, guanidinyl, hydrazine, hydrazide, thiohydrazide, and amino, or alternatively, R1 and R2 together form a five- or six-membered aromatic or aliphatic ring, and
- a) wherein the compound is part of a composition which further comprises phospholipids, and a weight ratio of said phospholipids to the compound in said composition is in a range of from 10:1 to 1:10,
- and/or
- b) wherein the compound is part of a composition which further comprises liposomes;
- thereby treating the coronavirus infection.
A method of treating a subject in need thereof, the method comprising administering to the subject a compound represented by Formula I:
- wherein R1-R6 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, sulfonate, sulfate, cyano, nitro, azide, phosphonyl, phosphinyl, carbonyl, thiocarbonyl, a urea group, a thiourea group, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, S-thiocarbamyl, C-amido, N-amido, C-carboxy, O-carboxy, sulfonamido, guanyl, guanidinyl, hydrazine, hydrazide, thiohydrazide, and amino, or alternatively, R1 and R2 together form a five- or six-membered aromatic or aliphatic ring and
- a) wherein said compound is part of a composition which further comprises phospholipids, and a weight ratio of said phospholipids to said compound in said composition is in a range of from 10:1 to 1:10,
- and/or
- b) wherein said compound is part of a composition which further comprises liposomes;
- thereby treating the subject.
Dependencies are inferred from the claim text.