# US 11,856,948 B2 · Colloidal particle formulations with advanced functionality

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- Number: US 11,856,948 B2
- Document ID: US11856948B2
- Status: Granted
- Kind: B2
- Application number: 17/644,745
- Filed: 2021-12-16
- Published: 2022-06-16
- Granted: 2024-01-02
- Earliest claimed: 2020-02-12
- Assignees: Benanova Inc.
- Applicants: Benanova Inc.
- Inventors: Anka Veleva
- Web page: https://patentgrep.com/patent/US11856948B2

## CPC

- A01N 25/22: containing ingredients stabilising the active ingredients
- A01N 25/04: Dispersions, {emulsions, suspoemulsions, suspension concentrates} or gels (foams A01N25/16)
- A01N 25/10: Macromolecular compounds
- A01N 59/20: Copper
- A01P 1/00: Disinfectants; Antimicrobial compounds or mixtures thereof
- C07G 1/00: Low-molecular-weight derivatives of lignin (high-molecular-weight derivatives of lignin {C08H6/00})
- C08L 97/00: Compositions of lignin-containing materials (of polysaccharides C08L1/00 - C08L5/00)
- C08L 97/005: {Lignin}
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- C07G: COMPOUNDS OF UNKNOWN CONSTITUTION (sulfonated fats, oils or waxes of undetermined constitution C07C309/62)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)

## Abstract

Disclosed is a method for creating a composite colloidal particle formulation with advanced functionality that possesses highly efficient and effective properties. The composite colloidal particle formulation comprises an engineered biodegradable particle core dispersed in a bioadhesive polyelectrolyte solution. Also disclosed are methods of use of the same, including but not limited to applying said formulation to plants for disease treatment.

## Claims

### Claim 1

A method of creating a composite colloidal particle formulation comprising an engineered biodegradable particle core dispersed in bioadhesive polyelectrolyte solution, the method comprising:
a. contacting an ethanol-based solvent containing dissolved biopolymer with an anti-solvent in a T-piece so as to form an engineered biodegradable particle core; and
b. dispersing the engineered biodegradable particle core in a bioadhesive polyelectrolyte solution comprising chitosan to form a composite colloidal particle formulation ready for administration to treat or prevent disease in plants,
wherein the composite colloidal particle formulation is fully biodegradable.

### Claim 2 (depends on 1)

The method of claim 1, wherein the method produces a final formulation volume of at least one liter.

### Claim 3

A method of producing final formulation volumes of at least one liter, of a composite colloidal particle formulation comprising an engineered biodegradable particle core, the method comprising: a. contacting an ethanol-based solvent containing dissolved biopolymer with an anti-solvent in a T-piece so as to form an engineered biopolymer particle core; and b. dispersing the engineered biodegradable particle core in a bioadhesive polyelectrolyte solution comprising chitosan to form a composite colloidal particle formulation ready for administration to treat or prevent disease in plants, wherein the composite colloidal particle formulation is fully biodegradable.