Phosphorylcholine group-containing polysiloxane monomer
AssigneeNof Corporation
InventorsYosuke Matsuoka, Akane Katori, Norio Iwakiri, Shu Takashima, Ryuya Gotanda, Nobuyuki Sakamoto
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Abstract
Provided is a monomer suitable for application to an ophthalmic device, the monomer showing high surface hydrophilicity, a high oxygen transmissibility, and appropriate mechanical strength when copolymerized with a polymerizable monomer, such as a hydrophilic monomer. It has been recognized that a phosphorylcholine group-containing polysiloxane monomer can solve the problems.
Claims10
A phosphorylcholine group-containing polysiloxane monomer, which is represented by the formula (1):
- where “a” represents an integer of from 20 to 500, “b” represents an integer of from 1 to 70, “c” represents 0 or 1, “p” and “q” each represent 0 or 1, and X represents —CH2— or —CH2CH2—.
A method of producing a phosphorylcholine group-containing polysiloxane monomer represented by the formula (1), the method comprising a step of subjecting a hydrosilyl group-containing di-methacrylate-terminated silicone represented by the formula (4) and an allyl group-containing phosphorylcholine compound represented by the formula (5) to an addition reaction:
- where “a” represents an integer of from 20 to 500, “b” represents an integer of from 1 to 70, “c” represents 0 or 1, “p” and “q” each represent 0 or 1, and X represents —CH2— or —CH2CH2—;
- where “a” represents an integer of from 20 to 500, “b” represents an integer of from 1 to 70, and “p” and “q” each represent 0 or 1;
- where “c” represents 0 or 1, and Z represents CH2═CHCH2— or CH2═CH—.
A monomer composition, comprising:
- 10 parts by weight to 60 parts by weight of a phosphorylcholine group-containing polysiloxane monomer represented by the formula (1);
- and
- 40 parts by weight to 90 parts by weight of one kind or a plurality of kinds of hydrophilic monomers:
- where “a” represents an integer of from 20 to 500, “b” represents an integer of from 1 to 70, “c” represents 0 or 1, “p” and “q” each represent 0 or 1, and X represents —CH2— or —CH2CH2—.
Dependencies are inferred from the claim text.