Back to results
US 11,851,391 B2Granted
Antifungal compounds and methods of forming the same
AssigneeUniversity of Kentucky Research Foundation
InventorsSylvie Garneau-Tsodikova, David S. Watt, Nishad Thamban Chandrika
Life of this patent
Estimating the term…
Abstract
An antifungal composition and a method of treating a systemic fungal infection are provided herein. The antifungal composition includes a diaryl bishydrazone. The method includes administering a therapeutically effective amount of the diaryl bishydrazone to a subject in need thereof.
Claims8
An antifungal composition comprising a compound according to Formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein each R is independently selected from the group consisting of H and a lower alkyl;
- and
- wherein each X is independently selected from the group consisting of phenyl, a substituted phenyl, an aromatic heterocycle, and a substituted aromatic heterocycle, so long as when both R are H or methyl then at least one X is not phenyl or meta-methoxy substituted phenyl;
- wherein the substituted phenyl comprises a substitution selected from the group consisting of nitro, an alkyl, an alkoxy, a halogen, cyano, a carboxylic acid, a sulfonic acid, aryl sulfoxides, aryl sulfones, a trihalomethyl, and combinations thereof;
- and
- aromatic heterocycle or the substituted aromatic heterocycle comprises one or more heteroatoms selected from the group consisting nitrogen, oxygen, sulfur, and combinations thereof, wherein the aryl sulfoxides include S(═O)C6H4Z, with Z being selected from the group consisting of alkyl, alkoxy, and halogen.
4 more elements
An antifungal composition comprising a compound according to Formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein each R is independently selected from the group consisting of H and a lower alkyl;
- and
- wherein each X is independently selected from the group consisting of phenyl, a substituted phenyl, an aromatic heterocycle, and a substituted aromatic heterocycle, so long as when both R are H or methyl then at least one X is not phenyl or meta-methoxy substituted phenyl;
- wherein the substituted phenyl comprises a substitution selected from the group consisting of nitro, an alkyl, an alkoxy, a halogen, cyano, a carboxylic acid, a sulfonic acid, aryl sulfoxides, aryl sulfones, a trihalomethyl, and combinations thereof;
- and
- aromatic heterocycle or the substituted aromatic heterocycle comprises one or more heteroatoms selected from the group consisting nitrogen, oxygen, sulfur, and combinations thereof, wherein the aryl sulfones include S(═O)2C6H4Z, with Z being selected from the group consisting of alkyl, alkoxy, and halogen.
4 more elements
An antifungal composition comprising a compound according to Formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein each R is independently selected from the group consisting of H and a lower alkyl;
- and
- wherein each X is independently selected from the group consisting of phenyl, a substituted phenyl, an aromatic heterocycle, and a substituted aromatic heterocycle, so long as when both R are H or methyl then at least one X is not phenyl or meta-methoxy substituted phenyl;
- wherein the substituted phenyl comprises a substitution selected from the group consisting of nitro, an alkyl, an alkoxy, a halogen, cyano, a carboxylic acid, a sulfonic acid, aryl sulfoxides, aryl sulfones, a trihalomethyl, and combinations thereof;
- and
- aromatic heterocycle or the substituted aromatic heterocycle comprises one or more heteroatoms selected from the group consisting nitrogen, oxygen, sulfur, and combinations thereof, wherein the substituent of the first ring according to Formula I is in the 3 position.
4 more elements
An antifungal composition comprising a compound according to Formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein each R is independently selected from the group consisting of H and a lower alkyl;
- and
- wherein each X is independently selected from the group consisting of phenyl, a substituted phenyl, an aromatic heterocycle, and a substituted aromatic heterocycle, so long as when both R are H or methyl then at least one X is not phenyl or meta-methoxy substituted phenyl;
- wherein the substituted phenyl comprises a substitution selected from the group consisting of nitro, an alkyl, an alkoxy, a halogen, cyano, a carboxylic acid, a sulfonic acid, aryl sulfoxides, aryl sulfones, a trihalomethyl, and combinations thereof;
- and
- aromatic heterocycle or the substituted aromatic heterocycle comprises one or more heteroatoms selected from the group consisting nitrogen, oxygen, sulfur, and combinations thereof, wherein the substituent of the first ring according to Formula I is in the 4 position.
4 more elements
An antifungal composition comprising a compound according to Formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein each R is independently selected from the group consisting of H and a lower alkyl;
- wherein X is a substituted phenyl and the substituted phenyl comprises a substitution selected from the group consisting of nitro, an alkyl, an alkoxy, a halogen, cyano, a carboxylic acid, a sulfonic acid, aryl sulfoxides, aryl sulfones, a trihalomethyl, and combinations thereof, wherein the substituted phenyl includes more than one substitution.
Dependencies are inferred from the claim text.