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US 11,850,335 B2Granted
Method for inhibiting platelet interaction with biomaterial surfaces
AssigneeMedtronic ATS Medical, Inc.
InventorBrian Pederson
Life of this patent
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Abstract
A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.
Claims13
A method for inhibiting blood platelet adhesion to a biomaterial surface, the method comprising:
- exposing the biomaterial surface to therapeutic energy in the presence of a proteinaceous fluid;
- and
- promoting conformationally modified fibrinogen at the biomaterial surface based on exposing the biomaterial surface to therapeutic energy,
- so that the conformationally modified fibrinogen comprises a higher concentration of beta fibrinogen as compared to a concentration of alpha fibrinogen and a concentration of gamma fibrinogen.
1 more element
Dependencies are inferred from the claim text.