Gene and cell therapy using cell fusion technology
AssigneeCuramys Inc.
InventorsJung-Joon Sung, Seung-Yong Seong, Hee-Woo Lee, Ki Yoon Kim
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Abstract
A gene and cell therapy using a cell fusion technology is proposed. Cells overexpressing hemagglutinin neuraminidase (HN) and fusion (F) proteins have effects of enhancing cell fusion with other cells, restoring cell damage through the cell fusion with damaged cells, and transferring a normal gene. Therefore, when a vector including genes encoding the HN and F proteins of the present invention or a cell transformed with the vector is clinically applied to neurodegenerative diseases, muscular diseases, and the like, an effect of reducing the damage of damaged cells through cell fusion can be expected.
Claims7
A method of fusing stem cells or progenitor cells to damaged nerve cells, comprising:
- administering stem cells or progenitor cells to the damaged nerve cells of a subject suffering from neurodegenerative diseases or neurological diseases,
- wherein the stem cells or progenitor cells are transformed with a vector including genes encoding hemagglutinin neuraminidase (HN) and fusion (F) proteins, and the stem cells or progenitor cells transformed with said vector express HN and F proteins and increase cell fusion with the damaged nerve cells compared to stem cells or progenitor cells not transformed with said vector.
Dependencies are inferred from the claim text.