Back to results
US 11,850,247 B2Granted
Antiviral compounds
AssigneesRegents of the University of Minnesota, Emory University
InventorsZhengqiang Wang, Stefanos G. Sarafianos
Life of this patent
Estimating the term…
Abstract
The invention provides a compound of formula I, formula II, or formula III: or a salt thereof, wherein R1-R10 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as HIV-1 CA-targeting molecules and as antiviral agents.
Claims20
A compound of formula I, formula II, or formula III:
- or a salt thereof, wherein:
- R1 is selected from the group consisting of:
- R2 is methyl or ethyl;
- R3 is phenyl, optionally substituted at the 3-position with bromo, chloro, fluoro, methyl, or methoxy, and optionally substituted at the 4-position with bromo, chloro, fluoro, methyl, or methoxy;
- R4 is 4-chloropyridyl, 4-bromopyridyl, or phenyl that is optionally substituted at the 4-position with halo, methyl, ethyl, or methoxy;
- R5 is selected from the group consisting of:
- R6 is a ring:
- which ring is optionally substituted with carboxy, (C1-C6)alkoxycarbonyl, or —C(═O)NRcRd;
- R7 is 4-chloropyridyl, 4-bromopyridyl, or phenyl that is optionally substituted at the 4-position with halo, methyl, ethyl, or methoxy;
- R8 is selected from the group consisting of:
- R9 is pyridyl that is substituted with phenyl, 4-chlorophenyl, 4-bromophenyl, 4-iodophenyl, or 4-cyanophenyl or R9 is imidazole that is substituted with phenyl, 4-chlorophenyl, 4-bromophenyl, 4-iodophenyl, or 4-cyanophenyl;
- R10 is 4-chloropyridyl, 4-bromopyridyl, or phenyl that is optionally substituted at the 4-position with halo, methyl, ethyl, or methoxy;
- Ra is H or methyl;
- Rb is phenyl that is optionally substituted with one or more groups independently selected from the group consisting of nitro, halo, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy, —SO2F, and NReRf;
- Rc is H, phenyl, benzyl, or (C1-C6)alkyl;
- Rd is H, phenyl, benzyl, or (C1-C6)alkyl;
- Re is H, hydroxy, or (C1-C6)alkyl;
- Rf is H or (C1-C6)alkyl;
- Rg is H, OH, or (C1-C6)alkoxy;
- and
- Rh is H or (C1-C6)alkyl.
18 more elements
The compound:
Dependencies are inferred from the claim text.