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US 11,845,959 B2Granted
Identification of factor that promotes human HSC self-renewal
AssigneeThe Regents of the University of California
InventorsHanna Mikkola, Vincenzo Calvanese, Andrew T. Nguyen
Life of this patent
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Abstract
Transient MLLT3 overexpression in culture may be used to expand human HSCs in vitro, and thereby improve the efficiency and safety of HSC transplantation.
Claims20
A method for promoting human hematopoietic stem cell self-renewal in vitro and engraftment in vivo comprising:
- a) introducing MLLT3 into a hematopoietic stem cell to generate an MLLT3-introduced hematopoietic stem cell;
- and,
- b) maintaining the MLLT3-introduced hematopoietic stem cell in culture for at least one week.
A method for promoting human hematopoietic stem cell self-renewal in vitro and engraftment in vivo comprising:
- a) introducing MLLT3 into a hematopoietic stem cell to generate an MLLT3-introduced hematopoietic stem cell;
- b) maintaining the MLLT3-introduced hematopoietic stem cell in culture with mesenchymal stem cell stromal cells for at least one week, wherein the MLLT3-introduced hematopoietic stem cell undergoes cell division without differentiation.
Dependencies are inferred from the claim text.