Klebsiella pneumoniae strain inducing inflammation in liver

A method of identifying a microorganism that causes the development of primary sclerosing cholangitis in a subject, the method comprising

• culturing a fecal sample collected from the subject and counting the number of cells of the microorganism, wherein the microorganism is Klebsiella pneumoniae,
• determining the proportion of Th17 cells in a liver tissue obtained from the subject and correlating the number of cells of the Klebsiella pneumoniae in the fecal sample to the proportion of the Th17 cells in the liver tissue by Spearman rank-order correlation test,
• detecting and counting the number of pores formed per mm2 unit area of a large intestinal epithelium tissue obtained from the subject using a scanning electron microscope, and
• wherein the presence of a correlation between the number of cells of the Klebsiella pneumoniae in the fecal sample of the subject and the proportion of the Th17 cells in the liver tissue of the subject combined with the formation of at least 40 pores with a pore size of 10 m or more per mm2 unit area of the large intestinal epithelium tissue identifies the Klebsiella pneumoniae as the microorganism that causes the development of primary sclerosing cholangitis.