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US 11,845,750 B1Granted
Antiproliferative selenated-folate hybrids
AssigneeKing Faisal University
InventorsAmr Negm, Saad Shaaban, Yasair S. Al-Faiz
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Abstract
Novel organoselenium compounds formed with folates that can be used to maximize anticancer activity of the organoselenium. Novel organoselenium compounds that can be used as a chemopreventive against cancer. These compounds may be present in pharmaceutical compositions and may be used in various treatment methods.
Claims10
A compound of formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- Y is selected from the group consisting of hydrogen, fluorine, NO2, methyl, and cyano.
A compound of formula II:
- it or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- Y is selected from the group consisting of hydrogen, fluorine, NO2, methyl, and cyano.
A compound of formula III:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- Y is selected from the group consisting of hydrogen, fluorine, NO2, methyl, and cyano.
A compound of formula IV:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- Y is selected from the group consisting of hydrogen, fluorine, NO2, methyl, and cyano.
A compound selected from the group consisting of:
- and a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof.
Dependencies are inferred from the claim text.