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US 11,845,735 B2Granted
Method for synthesizing (RS)-Warfarin
OwnerNasim Batooieinventor
Life of this patent
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Abstract
A method for synthesizing (RS)-Warfarin comprising preparing a liquid mixture, wherein the liquid mixture comprises trihexyltetradecylphosphonium bromide, methyl salicylate, acetyl chloride, benzaldehyde, and acetone. The method may further comprise incubating the liquid mixture at a temperature between 20° C. and 30° C. for a time duration between 26 and 34 minutes, and forming (RS)-Warfarin by adding water to the incubated liquid mixture with a volume ratio (water:incubated liquid mixture) between 1:1 and 1.5:1.
Claims13
A method for synthesizing (RS)-Warfarin, comprising:
- preparing a liquid mixture comprising:
- trihexyltetradecylphosphonium bromide with a concentration between 50.5% (w/w) and 53% (w/w);
- methyl salicylate with a concentration between 17.5% (w/w) and 19.5% (w/w);
- acetyl chloride with a concentration between 8.5% (w/w) and 10.5% (w/w);
- benzaldehyde with a concentration between 11.5% (w/w) and 14% (w/w);
- and
- acetone with a concentration between 6.5% (w/w) and 7.5% (w/w);
- incubating the liquid mixture at a temperature between 20° C. and 30° C. for a time duration between 26 and 34 minutes;
- and
- forming the (RS)-Warfarin by adding water to the incubated liquid mixture with a volume ratio (water:incubated liquid mixture) between 1:1 and 1.5:1.
7 more elements
A method for synthesizing (RS)-Warfarin, comprising:
- preparing a liquid mixture consisting of:
- trihexyltetradecylphosphonium bromide;
- methyl salicylate;
- acetyl chloride;
- benzaldehyde;
- and
- acetone;
- incubating the liquid mixture at a temperature between 20° C. and 30° C. for a time duration between 26 and 34 minutes;
- and
- forming the (RS)-Warfarin by adding water to the incubated liquid mixture with a volume ratio (water:incubated liquid mixture) between 1:1 and 1.5:1.
7 more elements
Dependencies are inferred from the claim text.