Method for photocleavage of amide bonds
AssigneeNanjing Tech University
InventorsXiaoqiang Chen, Tingwen Wei, Jing Wang, Yanyan Wang
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Abstract
The present disclosure provides a method for photocleavage of an amide bond, the method has mild reaction conditions and can realize the cleavage of amide bonds by using light. The method comprises the following steps: subjecting 2,4-dinitrofluorobenzene to a reaction with an amino group of a substance represented by structural formula I with an α-amino acid at the end to produce a compound 1 represented by structural formula II; then under light irradiation, subjecting the compound 1 to a cleavage reaction of amide bond; Wherein, R1 is the side chain group of α-amino acid; R2 is: aryl, aliphatic hydrocarbon, —CH(R)—COOH or polypeptide.
Claims7
A method for photocleavage of an amide bond, comprising the steps of
- subjecting 2,4-dinitrofluorobenzene to a reaction with an amino group of a substance represented by structural formula I with an α-amino acid at an end to produce a compound 1 represented by structural formula II;
- under light irradiation, subjecting the compound 1 to a cleavage reaction of the amide bond according to reaction equation 1:
- wherein R1 is a side chain group of α-amino acid;
- R2 aryl, aliphatic hydrocarbon group, or polypeptide group.
Dependencies are inferred from the claim text.