Chromatographic cassette
AssigneeSpf Technologies LLC
InventorGaston de los Reyes
Life of this patent
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Abstract
A chromatographic cassette includes a cassette including a chamber, chromatographic media disposed within the cassette chamber, a distribution network fluidly coupled to the chromatographic media and an inlet port and an outlet port coupled to the distribution network. A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.
Claims16
An adsorptive device comprising:
- a shell including a chamber;
- chromatographic media disposed within the chamber;
- a distribution network fluidly coupled to the chromatographic media;
- an inlet port and an outlet port coupled to the distribution network;
- wherein the chamber comprises a lattice;
- the chromatographic media comprises adsorptive beads;
- and
- wherein the shell further comprises a stackable shell having a feed distributor for distributing the feed stream across multiple adsorptive devices and an eluent distributor for collection of the eluent stream.
An adsorptive device comprising:
- a shell including a chamber;
- chromatographic media disposed within the chamber;
- a distribution network fluidly coupled to the chromatographic media;
- an inlet port and an outlet port coupled to the distribution network;
- and
- wherein the chromatographic media comprises one of:
- a monolithic block;
- a polymeric media;
- a hydrogel media;
- non-woven media;
- a compressible adsorptive media;
- and
- a semi-compressible adsorptive media.
An adsorptive device comprising:
- a shell including a chamber;
- chromatographic media disposed within the chamber;
- a distribution network fluidly coupled to the chromatographic media;
- and
- an inlet port and an outlet port coupled to the distribution network;
- wherein the adsorptive device further comprises:
- a top planar surface;
- a bottom planar surface,
- wherein the distribution network comprises a planar distributor and provides a direction of fluid flow through the chromatographic media which is perpendicular to the top and bottom planar surfaces of the adsorptive device;
- and
- wherein the planar distributor comprises one of:
- a type-II planar distributor;
- and
- a type-II isoflo planar distributor.
A chromatographic method to process a liquid flow comprising:
- providing an adsorptive device comprising:
- a shell including a chamber;
- chromatographic media disposed within the chamber;
- a distribution network fluidly coupled to the chromatographic media;
- and
- an inlet port and an outlet port coupled to the distribution network;
- wherein the adsorptive device further comprises:
- a top planar surface;
- a bottom planar surface,
- wherein the distributor network comprises a planar distributor and provides a direction of fluid flow through the chromatographic media which is perpendicular to the top and bottom planar surfaces of the adsorptive device;
- wherein the planar distributor comprises one of:
- a type-II planar distributor;
- and
- a type-II isoflo planar distributor;
- and
- stacking the plurality of stackable adsorptive devices within a holder and processing the liquid flow.
Dependencies are inferred from the claim text.